Please explain all these points in assignment to complete the requirement of this nicotine topic. Do not leave even single point-line below the structure.very important cover each dot-point in detail.

Reference: Harvard style

Please read each slide and file, which I attached with this assignment detail docx.

• To understand
  • where issue(NICOTINE) identification and hazard identification fits within the risk assessment framework
  • The types of scientific information critical in this step
• To be aware of
  • how to access relevant information ABOUT
  • emerging trends in hazard identification
  • how to get started gathering information about your assignment topic.NICOTINE
  • Consider the identity of your hazard NICOTINE.
  • CAS number
  • MSDS also now referred to as SDS (Safety Data Sheet)
  • What is the Chemical structure IS NICOTINE ????

1. What health benefits or impacts are associated with exposure? TO NICOTINE.
2. Why is it an issue? LIKE NICOTINE

E.g. Smoking, passive secondary smoking, tobacco

1. Who is it an issue for?
2. Is there a potential pathway of exposure? What is it?
3. Is there potential for interaction with other hazards/stressors? Eg smoking,tobacco
4. Can you identify a mode of action?
5. Are there any viable management options?
6. Does your hazard identification tell you that a risk assessment would be justified?

• Is there a susceptible subgroup in your population (e.g. lead in children)?
• What is the nature of the exposure - continuous, periodic, ‘one off’ etc.
• Can exposure be limited?
• Is any effect reversible?

Scientific reason e.g. Lab investigation, study.

Health effects of nicotine

• Others you can think of………

1. Does the information you have collected justify conducting a risk assessment?

• If no – why not?
• Choose another hazard and repeat this process

Additional sources of information to get started.

Identity of chemicals

• Chemspider: ChemSpider is a free chemical structure database providing fast access to over 34 million structures, properties, and associated information. By integrating and linking chemical compounds from ~500 data sources (http://www.chemspider.com )
• Material safety data sheets (MSDS) (do web search usually CAS number and MSDS in search term)
• ChemID Plus: a database of over 390,000 records including chemical structures (http://sis.nlm.nih.gov/chemical.html )
• AICS (Australian Inventory of Chemical Substances), National Industrial Chemicals Notification and Assessment (NICNAS), Department of Health, Australian Government. (http://www.nicnas.gov.au)

Guidelines (example given for drinking water)

• Australian Drinking Water Guidelines (NHMRC & NMMC, 2011)
• Australian Water Recycling Guidelines (2008) Phase 2. Augmentation of Surface Water Supplies, (NHMRC, NMMC & EPHC 2008)
• ANZECC/ARMCANZ (2000). Australian and New Zealand Guidelines for Fresh and Marine Water Volume 1, Australian and New Zealand Environment Conservation Council and Agriculture and Resource Management Council of Australia and New Zealand, Canberra.
• Health Canada (2012). Guidelines for Canadian Drinking Water Quality - Summary Table. Water, Air and Climate Change Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario.
• USEPA (2012) Drinking Water Standards and Health Advisories, EPA 820-R-11-002 Office of Water U.S. Environmental Protection Agency Washington, DC
• World Health Organisation (WHO) Drinking Water Guidelines (2011).

Toxicity data bases

• TOXNET® (TOXicology Data NETwork) (http://toxnet.nlm.nih.gov/) which is a group of databases covering specific chemicals and products. Databases from TOXNET® included the Hazardous Substances Data Bank (HSDB), the Integrated Risk Information System (IRIS), GENETOX and Toxline®.
• OECD (SIDS): The "Screening Information Data Set" (SIDS) program operated under the auspices of the Organization for Economic Cooperation and Development (OECD) is a voluntary cooperative international testing program that began in 1989. The SIDS program is focused on developing base level test information on approximately 600 poorly characterized international high production volume (HPV) chemicals.
• IARC (International Agency for Research on Cancer). Monographs on the Evaluation of Carcinogenic Risks to Humans.
• HERA. Human and environmental risk-assessment of components of house-hold cleaning products. Website: http://www.heraproject.com/Index.cfm
• PBT profiler: Persistent, Bio-accumulative, and Toxic (PBT) Profiles Estimated for Organic Chemicals http://www.pbtprofiler.net/

Task

 your final critical review contributes to 35% of your overall grade for this course.your final review document will:

• address all four key areas of the environmental health risk management process (including dose response data);
• identify knowledge gaps; and • provide recommendations for future research.

Structural Format:

• Introduction •

Search methodology

• Body of the review
• Conclusions
• Recommendations for future research

Task Description:

This task requires you to prepare a critical review drawing upon international literature regarding an assigned chemical hazard.

You will submit 2 pieces of assessment for this task as per the Course Outline and detailed below.

Task 1a is a voluntary formative assessment task. You will complete a template that provides a summary of your research strategy and findings and outlines the structure of your critical review. You will get the opportunity to receive face-to-face feedback on this task in the Week 4 workshop

Task 1b, your final critical review contributes to 35% of your overall grade for this course.your final review document will:

• address all four key areas of the environmental health risk management process (including dose response data);
• identify knowledge gaps; and
• provide recommendations for future

Structural Format:

• Introduction
• Search methodology
• Body of the review
• Conclusions
• Recommendations for future research